Interdisciplinary bio-hacking team finds genetic stability key to turning off ageing

A group of scientists led a life extension world record holder has determined that stabilising gene networks is key to switching off the process of ageing.

The team, from Hong Kong-based biohacking company Gero, comprises experts from a vast array of different scientific backgrounds, alongside Professor Robert J Shmookler Reis, the current world record holder in life extension for model animals, and has just published research on the subject in the journal Scientific Reports.

“In our work, we analyzed the stability of a simple gene network model and found that gene networks describing most common species are inherently unstable,” explained Dr Peter Fedichev, CSO of Gero.

“Over time, it undergoes exponential accumulation of gene regulation deviations leading to diseases and death.

“We conjectured, that the instability is the cause of aging. However, should the repair systems be sufficiently effective, the gene network can stabilize so that the damage to the gene regulation can remain constrained along with mortality of the organism.”

mole-rat

This theory is supported by the genetic networks of animals that do not experience a decline in function or a rise in mortality as they get older. The team gave the example of naked mole rats, which are negligibly senescent – ie they barely age – and have highly stress-resistant tissue due to the stability of their gentic networks.

By contrast, humans’ genetic networks are very unstable, resulting in a decline in human tissue’s ability to reproduce, regenerate and resist stress, resulting in our increase in mortality and decline in function as we age.

These differences are caused by a small number of major factors, including how effective genes are connected as a network, the rate DNA repairs itself, the turnover of proteome – the proteins expressed by a gene – and genome size, and the team at Gero believes that lifespan can be altered by ‘hacking’ any of these aspects.

This has already been achieved in a type of worm – C. elegans – creating a lifespan ten times the norm with a single gene mutation, and it is thought that it can be achieved in other creatures with further work.

The genes of the worm C. elegans were successfully altered to significantly improve its lifespan.

The genes of the worm C. elegans were successfully altered to significantly improve its lifespan.

Gero is working with the intention of creating anti-ageing treatments, and believes that this approach is key to creating such therapeutics.

“We want to create a drug that will significantly extend a healthy and happy human life,” said the company on their website.

“The relation between stresses, stress resistance and aging is analyzed and demonstrates that damage to gene regulation from stresses encountered even at a very young age can persist for a very long time and influence lifespan,” explained the company in a media release to accompany the publication of the research.

“That is why we believe that further research into the relation between gene network stability and aging will make it possible to create entirely new therapies with potentially strong and lasting effect against age-related diseases and aging itself.”

Oxford University develops new 3D bioprinter

University of Oxford scientists have developed a new method for 3D printing laboratory-grown cells to form living structures. The new method enables the production of complex tissues and cartilage that can potentially support, repair and augment diseased and damaged areas of the body.

Google spinoff patents flexible cars that protect pedestrians

Waymo has patented a car design that is capable of becoming flexible or rigid depending on need, so if sensors detect the vehicle is about to hit another object the car would change accordingly. If it’s another car, the car could turn stiff; if it’s a human, the car could loosen up and soften its impact.

Source: The Verge

Researcher who killed WannaCry denies writing banking malware

Marcus Hutchins, the British security researcher credited with halting the virulent WannaCry ransomware worm that shut down computers worldwide in May, pleaded not guilty to unrelated charges that he created and distributed malware that steals banking credentials.

Source: Ars Technica

Record-sized data centre to be built inside Arctic Circle

US-Norwegian firm Kolos has revealed plans to build the world's largest data centre in the town of Ballangen, inside the Arctic Circle. The centre will cover 600,000 square metres over four stories, and would eventually draw on over 1,000MW of power.

Source: BBC

AI bot competes in e-sports tournament and wins

A bot from Elon Musk's artificial intelligence company OpenAI has beaten one of the world's best players of the e-sports video game "Dota 2". OpenAI's bot won a 1v1 match, but the company says it hopes to have it ready to compete in a five-on-five match next year.

Scientists solve the mystery of the "Frankenstein dinosaur"

Scientists have solved the puzzle of the so-called "Frankenstein dinosaur", which seems to consist of body parts from unrelated species. A new study suggests that it is in fact the missing link between plant-eating dinosaurs and carnivorous dinosaurs.

Source: BBC

Steve “Woz” Wozniak to advise hologram emoji company that he calls “groundbreaking”

Apple’s co-founder Steve “Woz” Wozniak has found himself a new gig; Woz has joined the hologram emoji company, Mojiit, as an adviser.

In his role as advisor to Mojiit, the legendary entrepreneur and engineer will help assemble a world-class engineering team in addition to bringing investors and partnerships to the newly launched startup. Wozniak will also serve as mentor to Mojiit founder, Jeremy Greene.

“I’m thrilled to join Mojiit as an advisor,” said Wozniak. “Jeremy is a natural leader, the company is groundbreaking, it’s going to change the ecommerce space, and it’s a lot of fun.”

Created in 2017, Mojiit is the latest startup technology venture from Greene. The company’s tech essentially enables users to project and share 3D hologram emojis via smartphones.

The platform turns users into emojis by scanning their face, which can then be sent to loved ones and friends. Once a Mojiit message is received, it will map the area where it is received and place the Mojiit hologram there in real time, so it works in a similar way to Pokemon Go.

“Steve is one of the best and brilliant engineers in the entire world. But outside of that, he’s a wonderful man,” said Greene. “There isn’t anyone I’d want to be in business with more than this guy. He’s a legend. Who better to learn from than the guy who created the computer?”

Image courtesy of Nichollas Harrison. Featured image courtesy of Mojiit

In addition to consumer use, businesses of all kinds can tap into hologram emojis with Mojiit’s technology.

Mojiit investors already  include NFL alum Ed Reed, and the company was able to raise a total of $1 million in its seed round of funding.

Alongside the appointment of Woz, Entourage and Ballers producer Rob Weiss recently joined the company as a creative director.

“It’s exciting to expand beyond television and film to digital platforms,” said Weiss. “Hologram technology brings incredible opportunity to entertainment and media. I’m thrilled to be leading creative at Mojiit.”