Interdisciplinary bio-hacking team finds genetic stability key to turning off ageing

A group of scientists led a life extension world record holder has determined that stabilising gene networks is key to switching off the process of ageing.

The team, from Hong Kong-based biohacking company Gero, comprises experts from a vast array of different scientific backgrounds, alongside Professor Robert J Shmookler Reis, the current world record holder in life extension for model animals, and has just published research on the subject in the journal Scientific Reports.

“In our work, we analyzed the stability of a simple gene network model and found that gene networks describing most common species are inherently unstable,” explained Dr Peter Fedichev, CSO of Gero.

“Over time, it undergoes exponential accumulation of gene regulation deviations leading to diseases and death.

“We conjectured, that the instability is the cause of aging. However, should the repair systems be sufficiently effective, the gene network can stabilize so that the damage to the gene regulation can remain constrained along with mortality of the organism.”

mole-rat

This theory is supported by the genetic networks of animals that do not experience a decline in function or a rise in mortality as they get older. The team gave the example of naked mole rats, which are negligibly senescent – ie they barely age – and have highly stress-resistant tissue due to the stability of their gentic networks.

By contrast, humans’ genetic networks are very unstable, resulting in a decline in human tissue’s ability to reproduce, regenerate and resist stress, resulting in our increase in mortality and decline in function as we age.

These differences are caused by a small number of major factors, including how effective genes are connected as a network, the rate DNA repairs itself, the turnover of proteome – the proteins expressed by a gene – and genome size, and the team at Gero believes that lifespan can be altered by ‘hacking’ any of these aspects.

This has already been achieved in a type of worm – C. elegans – creating a lifespan ten times the norm with a single gene mutation, and it is thought that it can be achieved in other creatures with further work.

The genes of the worm C. elegans were successfully altered to significantly improve its lifespan.

The genes of the worm C. elegans were successfully altered to significantly improve its lifespan.

Gero is working with the intention of creating anti-ageing treatments, and believes that this approach is key to creating such therapeutics.

“We want to create a drug that will significantly extend a healthy and happy human life,” said the company on their website.

“The relation between stresses, stress resistance and aging is analyzed and demonstrates that damage to gene regulation from stresses encountered even at a very young age can persist for a very long time and influence lifespan,” explained the company in a media release to accompany the publication of the research.

“That is why we believe that further research into the relation between gene network stability and aging will make it possible to create entirely new therapies with potentially strong and lasting effect against age-related diseases and aging itself.”

Google’s Alphabet is Developing the Neighbourhood of the Future in Toronto

Alphabet, the parent company of Google, has announced that Sidewalk Labs, its urban innovation unit, will design a high-tech neighbourhood on Toronto’s waterfront. The neighbourhood, called Quayside, will prioritise, “environmental sustainability, affordability, mobility and economic opportunity”.

The initial phase for the development, part of the broader Sidewalk Toronto project, has received a $50m commitment from Sidewalk, but is predicted to cost at least a billion dollars by the time it’s fully completion.

As part of the broader project, Quayside seems to be the first attempt at creating what Sidewalk refers to as a “new kind of mixed-use, complete community”, an attempt the company presumably hopes to eventually expand across the waterfront and ultimately into other cities.

“This will not be a place where we deploy technology for its own sake, but rather one where we use emerging digital tools and the latest in urban design to solve big urban challenges in ways that we hope will inspire cities around the world,” Sidewalk Labs CEO Dan Doctoroff said on Tuesday.

Early concept images for the neighbourhood include self-driving cars and other infrastructure technologies. Images courtesy of Sidewalk Toronto

Located in the primarily publicly-owned 800-acre area called Port Lands, Quayside looks to be the test bed for potential future community design. With the planning process for the development starting with a community town hall on the 1st of November, we are still some ways off from knowing just what the neighbourhood will look like, but early illustrations include bikeshares, apartment housing, bus lines and parks.

More importantly, however, is Doctoroff’s previous discussions of what he believes future city design will look like. Technology focused, there’s been mention of sensors that track energy usage, machine learning and using high-speed internet to improve urban environments.

Specifically, at a summit hosted by The Information last year, he mentioned “thinking about [a city] from the internet up”. As would be expected from a company under the same parent as Google, Sidewalk seems to be concentrated on development that prioritises innovation and building communities with an eye to how technology can help found neighbourhoods.

“I like to describe it that we’re in the very early stages of what I call the fourth revolution of urban technology,” Doctoroff previously told Business Insider.

“The first three were the steam engine, which brought through trains and factories that industrialized cities. The second was the electric grid, which made cities 24 hours, made them more vertical, made them easier to get around in with subways and streetcars.

“The third was the automobile, which forced us to really re-think the use of public space in order to protect people from the danger of the automobile. We’re now in the fourth one. We’ve had an urban technology revolution … We’re seeing a real change in the physical nature of our cities.”

DJI’s First Drone Arena in Tokyo to Open This Saturday

Consumer drone giant DJI will open its first Japanese drone arena in the city of Tokyo this Saturday, providing a space for both hardened professionals and curious newcomers to hone their flying skills.

The arena, which covers an area of 535 square metres, will not only include a large flying area complete with obstacles, but also offer a store where visitors can purchase the latest DJI drones and a technical support area where drone owners can get help with quadcopter issues.

The hope is that the arena will allow those who are curious about the technology but currently lack the space to try it out to get involved.

“As interest around our aerial technology continues to grow, the DJI Arena concept is a new way for us to engage not just hobbyists but also those considering this technology for their work or just for the thrill of flying,” said Moon Tae-Hyun, DJI’s director of brand management and operations.

“Having the opportunity to get behind the remote controller and trying out the technology first hand can enrich the customer experience. When people understand how it works or how easy it is to fly, they will discover what this technology can do for them and see a whole new world of possibilities.”

Images courtesy of DJI

In addition to its general sessions, which will allow members of the public to drop by and try their hand at flying drones, the arena will also offer private hire, including corporate events. For some companies, then, drone flying could become the new golf.

There will also be regular events, allowing pros to compete against one another, and drone training, in the form of DJI’s New Pilot Experience Program, for newcomers.

The arena has been launched in partnership with Japan Circuit, a developer of connected technologies, including drones.

“We are extremely excited to partner with DJI to launch the first DJI Arena in Japan,” said Tetsuhiro Sakai, CEO of Japan Circuit.

“Whether you are a skilled drone pilot or someone looking for their first drone, we welcome everyone to come and learn, experience it for themselves, and have fun. The new DJI Arena will not only serve as a gathering place for drone enthusiasts but also help us reach new customers and anyone interested in learning about this incredible technology.”

The arena is the second of its kind to be launched by DJI, with the first located in Yongin, South Korea, and detailed in the video above. .

Having opened in 2016, the area has attracted visitors from around the world, demonstrating serious demand for this type of entertainment space.

If the Tokyo launch goes well, it’s likely DJI will look at rolling out its arena concept to other cities, perhaps even bringing the model to the US and Europe.

For now, however, those who are interested can book time at the Tokyo arena here.