First new sound wave class in half a century to revolutionise stem cell therapy

A new class of sound wave has been developed for the first time in 50 years that looks set to revolutionise the use of stem cells in medical treatments.

Created by acoustics experts from RMIT University in Melbourne, Australia, the sound waves – known as “surface reflected bulk waves” – are gentle enough to manipulate stem cells without causing damage, something that has not previously been possible with sound waves.

The researchers have already used the technology to significantly improve the efficiency of an advanced nebuliser device developed at RMIT, which delivers medicine directly to the lungs.

“We have used the new sound waves to slash the time required for inhaling vaccines through the nebuliser device, from 30 minutes to as little as 30 seconds,” said study co-author Dr Amgad Rezk, from the Micro/Nano Research Laboratory at RMIT.

“But our work also opens up the possibility of using stem cells more efficiently for treating lung disease, enabling us to nebulise stem cells straight into a specific site within the lung to repair damaged tissue. This is a real game changer for stem cell treatment in the lungs.”

Amgad-Rezk

Dr Amgad Rezk, who co-authored the study with PhD researcher James Tan.

Surface reflected bulk waves are known as such due to their combination of bulk sound waves and surface sound waves.

Bulk sound waves cause an entire material to vibrate as one, an effect that the researchers liken to holding a carpet at one end and shaking it.

By contrast, surface sound waves only cause the surface of a material to vibrate, with the researchers comparing the effect to waves in an ocean.

By combining the two, the researchers have created a sound wave class that is far more powerful than its component wave types.

“The combination of surface and bulk wave means they work in harmony and produce a much more powerful wave,” said Rezk.

“As a result, instead of administering or nebulising medicine at around 0.2ml per minute, we did up to 5ml per minute. That’s a huge difference.”

Professor Leslie Yeo, also of RMIT, demonstrates the Respite nebuliser, which this research has improved. Images courtesy of RMIT.

Professor Leslie Yeo, also of RMIT, demonstrates the Respite nebuliser, which this research has improved. Inline images courtesy of RMIT.

The researchers have created a device to utilise surface reflected bulk waves in medical devices with the rather epic name HYDRA.

This passes electricity through a piezoelectric chip, converting it into mechanical vibration, or sound waves, that can break liquid into a spray so it can be inhaled.

“It’s basically ‘yelling’ at the liquid so it vibrates, breaking it down into vapour,” explained Rezk.

HYDRA has been used to improve RMIT’s advanced nebula, known as Respite, which can be used to deliver a wide range of drugs into the body without the need for pills or injections.

For sufferers of asthma and cystic fibrosis, the device can deliver highly precise drug doses, but it can also be used to provide diabetes patients with insulin, and give infants vaccines without an injection.

The details of the research have been published today in the journal Advanced Materials.

Factor’s Gift Guide: 10 Gifts for Geeks and Scifi Supremos

Stuck trying to find a present for the geek or science fiction fan in your life? We’ve got the answer, with 10 fun but nerdy ideas for gifts this Christmas.

Pluto Plush

£14.95 from getDigital

pluto-plush

The change of Pluto’s status from planet to dwarf planet was hard to bear and has to have been an emotional blow to the planet itself. Luckily you now have the chance to provide poor Pluto some comfort with this 1:17,000,000 plush. With the heart and arms based on the famous images sent from NASA’s New Horizons space probe, this is probably the friendliest the ice planet has ever been.

Cross Marvel Tech2 Iron Man Gift Set

£65 from Cross

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To commemorate three of the most iconic characters from the Marvel franchise – Captain America, Spider-Man, and Iron Man – Cross have paired up their Tech2 Marvel pens with high quality journals to produce the perfect gift set for the Marvel fan in your life. And just in case the looks alone weren’t enough to sell you on this, the pen itself switches between stylus and ballpoint to work with touchscreens.

Spiral Planetary Nebula Mural

£25+ from Murals Wallpaper

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Showing the planetary nebula NGC 5189, this mural is a beautiful addition to any astronomically inclined home. The image, captured by NASA’s Hubble Wide Field Camera, shows the star as it consumes the last remaining fuel from its core and expels glowing clouds of gas. Lighting up the darkness of space with the bright gases of sulphur, hydrogen and oxygen, this mural adds some stellar colour to any home.

Robocup

€20.95 from MonsterZeug

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A great gift for fans of the ‘80s classic, this Robocop mug combines high quality ceramic with the grim visage of a cyborg to satisfy all caffeine needs. Once designed to fight crime, the part-man part-machine now serves to deliver your morning coffee. So whether you’re a fan yourself, or just trying to help a friend get over the reboot, be sure to add this to your Christmas list.

Zeitia Polygon Chrome Chandelier

£1,000 from The Chandelier & Mirror Company

zeitia-polygon-chrome-chandelier

If you want a lighting fixture for a geometrically inclined friend, this is the chandelier for you. Finished in chrome and composed of LED lights, the polygonal piece is sure to be as much of a talking piece as a source of illumination. Suitable for any room in the home, it may be pricey, but you’re unlikely to see much else like it.

Zero Gravity Fridge Rover

£4.99 from Mulberry Bush

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A brilliant little wind up car for any space geeks out there, the Fridge Rover makes use of magnets and a clockwork mechanism to defy gravity. A nice stocking filler, just wind it up and put it on your fridge to see the rover at work as it grips and goes. The science can be kept a secret, but the fun is certain to be obvious.

Scientific Lab Flasks

£14 from Not Another Bill

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Whether your recipients are just after décor that’s a little quirkier than usual or needing some new glassware for those secret experiments, these flasks have you covered. Each with 100ml or 250ml measurements, the glass homeware set features one beaker and two flasks. Bring a little science to your sauces by using them for measuring, or make your centrepiece a little more experimental and place them as a vase.

Townsend Star Wars R2-D2 Fountain Pen

£575 from Cross

townsend-star-wars-limited-edition-r2-d2-fountain-pen

You don’t need to go to a galaxy far, far away to get a great gift for the Star Wars fan in your life this Christmas. Instead, grab this limited edition pen to commemorate the original movie. With deep-etched engravings on brushed platinum plate and presented in a luxury gift box, each of these pens is individually serialised. Well worthy of a triumphant whistle.

LEGO Doctor Who Set

£49.99 from Forbidden Planet

lego-doctor-who-set

LEGO continues its trend of producing the best licensed products out there with this Doctor Who set. Created by fan-designer Andrew Clark, this set brings together the Doctor and Clara inside the Tardis to face some of their iconic enemies. Choose from the Eleventh or Twelfth Doctor and then set him against a pair of Daleks or a Weeping Angel. Don’t blink, though, or you might miss this amazing gift.

Human Ingredients T-Shirt

£20 from the Science Museum Shop

human-ingredients-t-shirt

Ever wondered just what it is that goes into making you, well, you? Wonder no more, as the Science Museum has you covered with this handy t-shirt. Presented in the manner of a food label, the t-shirt’s design lists the most commonly found elements in the human body. Your nearest and dearest will never be caught out by the pub quiz again as right in front of their nose is the answer: they’re 65% oxygen.

If you had to retake control of a driverless car would you be ready?

Researchers from Stanford University have concluded that drivers who retake control of an autonomous car are more likely to be involved in an accident.

The study, published in the first issue of Science Robotics, found that roads could become especially dangerous when drivers made the transition back to being in control of autonomous vehicles due to changes in speed and other changes in driving conditions.

“Many people have been doing research on paying attention and situation awareness. That’s very important,” said lead author of the research and former graduate student in the Dynamic Design Lab at Stanford University, Holly Russell.

“But, in addition, there is this physical change and we need to acknowledge that people’s performance might not be at its peak if they haven’t actively been participating in the driving.”

Featured image courtesy of Steve Jurvetson

Featured image courtesy of Steve Jurvetson

During testing all drivers were given advance warning that they would be put back in control of a driverless car and were given the opportunity to drive around the testing track a number of times, so they could feel for themselves changes in speed or steering that may occur while the car drives itself.

However, during the trial itself, the drivers’ steering manoeuvres differed significantly from their ability when in control of the car from start to finish.

“Even knowing about the change, being able to make a plan and do some explicit motor planning for how to compensate, you still saw a very different steering behaviour and compromised performance,” said co-author of the research and research associate in the Revs Program at Stanford, Lene Harbott.

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Although no driver was so thrown off by the changes in steering that they drove off-course, the fact that there was a period of altered steering behaviour increased the likelihood of an accident occurring.

However, the Stanford study only addressed one specific example of the autonomous car to human driver handover; there is still a lot to learn about how people respond in other circumstances, depending on the type of car, the driver and how the driving conditions have changed.

“If someone is designing a method for automated vehicle handover, there will need to be detailed research on that specific method,” said Harbott. “This study is tip of an iceberg.”