First new sound wave class in half a century to revolutionise stem cell therapy

A new class of sound wave has been developed for the first time in 50 years that looks set to revolutionise the use of stem cells in medical treatments.

Created by acoustics experts from RMIT University in Melbourne, Australia, the sound waves – known as “surface reflected bulk waves” – are gentle enough to manipulate stem cells without causing damage, something that has not previously been possible with sound waves.

The researchers have already used the technology to significantly improve the efficiency of an advanced nebuliser device developed at RMIT, which delivers medicine directly to the lungs.

“We have used the new sound waves to slash the time required for inhaling vaccines through the nebuliser device, from 30 minutes to as little as 30 seconds,” said study co-author Dr Amgad Rezk, from the Micro/Nano Research Laboratory at RMIT.

“But our work also opens up the possibility of using stem cells more efficiently for treating lung disease, enabling us to nebulise stem cells straight into a specific site within the lung to repair damaged tissue. This is a real game changer for stem cell treatment in the lungs.”

Amgad-Rezk

Dr Amgad Rezk, who co-authored the study with PhD researcher James Tan.

Surface reflected bulk waves are known as such due to their combination of bulk sound waves and surface sound waves.

Bulk sound waves cause an entire material to vibrate as one, an effect that the researchers liken to holding a carpet at one end and shaking it.

By contrast, surface sound waves only cause the surface of a material to vibrate, with the researchers comparing the effect to waves in an ocean.

By combining the two, the researchers have created a sound wave class that is far more powerful than its component wave types.

“The combination of surface and bulk wave means they work in harmony and produce a much more powerful wave,” said Rezk.

“As a result, instead of administering or nebulising medicine at around 0.2ml per minute, we did up to 5ml per minute. That’s a huge difference.”

Professor Leslie Yeo, also of RMIT, demonstrates the Respite nebuliser, which this research has improved. Images courtesy of RMIT.

Professor Leslie Yeo, also of RMIT, demonstrates the Respite nebuliser, which this research has improved. Inline images courtesy of RMIT.

The researchers have created a device to utilise surface reflected bulk waves in medical devices with the rather epic name HYDRA.

This passes electricity through a piezoelectric chip, converting it into mechanical vibration, or sound waves, that can break liquid into a spray so it can be inhaled.

“It’s basically ‘yelling’ at the liquid so it vibrates, breaking it down into vapour,” explained Rezk.

HYDRA has been used to improve RMIT’s advanced nebula, known as Respite, which can be used to deliver a wide range of drugs into the body without the need for pills or injections.

For sufferers of asthma and cystic fibrosis, the device can deliver highly precise drug doses, but it can also be used to provide diabetes patients with insulin, and give infants vaccines without an injection.

The details of the research have been published today in the journal Advanced Materials.

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Juno mission: Jupiter’s magnetic field is even weirder than expected

It has long been known that Jupiter has the most intense magnetic field in the solar system, but the first round of results from NASA’s Juno mission has revealed that it is far stronger and more misshapen than scientists predicted.

Announcing the findings of the spacecraft’s first data-collection pass, which saw Juno fly within 2,600 miles (4,200km) of Jupiter on 27th August 2016, NASA mission scientists revealed that the planet far surpassed the expectations of models.

Measuring Jupiter’s magnetosphere using Juno’s magnetometer investigation (MAG) tool, they found that the planet’s magnetic field is even stronger than models predicted, at 7.766 Gaus: 10 times stronger than the strongest fields on Earth.

Furthermore, it is far more irregular in shape, prompting a re-think about how it could be generated.

“Juno is giving us a view of the magnetic field close to Jupiter that we’ve never had before,” said Jack Connerney, Juno deputy principal investigator and magnetic field investigation lead at NASA’s Goddard Space Flight Center in Greenbelt, Maryland.

“Already we see that the magnetic field looks lumpy: it is stronger in some places and weaker in others.

An enhanced colour view of Jupiter’s south pole. Image courtesy of NASA/JPL-Caltech/SwRI/MSSS/Gabriel Fiset. Featured image courtesy of NASA/SWRI/MSSS/Gerald Eichstädt/Seán Doran

At present, scientists cannot say for certain why or how Jupiter’s magnetic field is so peculiar, but they do already have a theory: that the field is not generated from the planet’s core, but in a layer closer to its surface.

“This uneven distribution suggests that the field might be generated by dynamo action closer to the surface, above the layer of metallic hydrogen,” said Connerney.

However, with many more flybys planned, the scientists will considerable opportunities to learn more about this phenomenon, and more accurately pinpoint the bizarre magnetic field’s cause.

“Every flyby we execute gets us closer to determining where and how Jupiter’s dynamo works,” added Connerney.

With each flyby, which occurs every 53 days, the scientists are treated to a 6MB haul of newly collected information, which takes around 1.5 days to transfer back to Earth.

“Every 53 days, we go screaming by Jupiter, get doused by a fire hose of Jovian science, and there is always something new,” said Scott Bolton, Juno principal investigator from the Southwest Research Institute in San Antonio.

A newly released image of Jupiter’s stormy south pole. Image courtesy of NASA/JPL-Caltech/SwRI/MSSS/Betsy Asher Hall/Gervasio Robles

An unexpected magnetic field was not the only surprise from the first data haul. The mission also provided a first-look at Jupiter’s poles, which are unexpectedly covered in swirling, densely clustered storms the size of Earth.

“We’re puzzled as to how they could be formed, how stable the configuration is, and why Jupiter’s north pole doesn’t look like the south pole,” said Bolton. “We’re questioning whether this is a dynamic system, and are we seeing just one stage, and over the next year, we’re going to watch it disappear, or is this a stable configuration and these storms are circulating around one another?”

Juno’s Microwave Radiometer (MWR) also threw up some surprises, with some of the planet’s belts appearing to penetrate down to its surface, while others seem to evolve into other structures. It’s a curious phenomenon, and one which the scientists hope to better explore on future flybys.

“On our next flyby on July 11, we will fly directly over one of the most iconic features in the entire solar system – one that every school kid knows – Jupiter’s Great Red Spot,” said Bolton.

“If anybody is going to get to the bottom of what is going on below those mammoth swirling crimson cloud tops, it’s Juno and her cloud-piercing science instruments.”