Stem cell therapy restores sight to blind mice

A transplantation treatment based on stem cells has moved closer to being tested in humans with severe vision problems, after successful trials in mice.

The method, which was shown to restore visual function in half of mice with end-stage retinal degeneration, involved transplanting retinal tissue derived from mouse induced pluripotent stem cells (iPSCs) into the host retina.

In order to create the transplant tissue, researchers first genetically reprogrammed skin cells taken from adult mice to an embryonic stem cell-like state before converting these iPSCs into retinal tissue. When transplanted into mice with end-stage retinal degeneration, the iPSC-derived retinal tissue developed to form photoreceptors that established direct contact with neighbouring cells in the retina.

The treatment, developed by senior study author Masayo Takahashi and first author Michiko Mandai of the RIKEN Center for Developmental Biology, was able to restore vision in roughly half of the mice with end-stage retinal degeneration. The research team are now testing the ability to replicate the results using human-derived iPSC retinal tissue.

“It is still a developing-stage therapy, and one cannot expect to restore practical vision at the moment,” Takahashi cautioned. “We will start from the stage of seeing a light or large figure, but hope to restore more substantial vision in the future.”

End-stage retinal degeneration is a leading cause of irreversible vision loss and blindness in older individuals. There is currently no cure and therapies are limited in their capability to stop the progression of vision loss.

The therapy strategy used by the RIKEN team is that of cell replacement, a method that, until now, suffered from uncertainty as to whether transplantation of stem cell tissues could actually restore visual function.

The key to success found by the researchers was the use of differentiated retinal tissues as opposed to retinal cells, which have previously been the focus of field use for most researchers. In almost all of the retinas that were transplanted, the researchers found at least some measure of response to light stimulation.

“The photoreceptors in the 3D structure can develop to form more mature, organized morphology, and therefore may respond better to light,” Takahashi explains. “From our data, the post-transplantation retina can respond to light already at one month in mice, but since the human retina takes a longer time to mature, it may take five to six months for the transplanted retina to start responding to light.”

Although simple light perception isn’t full restoration of sight, it is indicative of the possibilities of the treatment and shows that visual functions can be restored.

Takahashi’s acknowledgement of the increased complexity of human cells requires bearing in mind; it will not be a simple switchover from mice to human patients. However, if their new experiments into human-derived tissues prove successful, it may not be long before work can begin transferring this restorative success to clinical trials.

School will use facial analysis to identify students who are dozing off

In September the ESG business school in Paris will begin using artificial intelligence and facial analysis to determine whether students are paying attention in class. The school says the technology will be used to improve performance of students and professors.

Source: The Verge

Company offers free training for coal miners to become wind farmers

A Chinese wind-turbine maker wants American workers to retrain and become wind farmers. The training program was announced at an energy conference in Wyoming, where the American arm of Goldwind, a Chinese wind-turbine manufacturer is located.

Source: Quartz

Google AI defeats human Go champion

Google's DeepMind AI AlphaGo has defeated the world's number one Go player Ke Jie. AlphaGo secured the victory after winning the second game in a three-part match. DeepMind founder Demis Hassabis said Ke Jie "pushed AlphaGo right to the limit".

Source: BBC

Vegan burgers that taste like real meat to hit Safeway stores

Beyond Meat, which promises its plant-based burgers bleed and sizzle like real ground beef and is backed by investors like Bill Gates, will begin distributing its plant-based burgers in more than 280 Safeway stores in California, Hawaii and Nevada.

Source: Bloomberg

The brain starts to eat itself after chronic sleep deprivation

Brain cells that destroy and digest worn-out cells and debris go into overdrive in mice that are chronically sleep-deprived. The discovery could explain why a chronic lack of sleep puts people at risk of neurological disorders like Alzheimer’s disease.

Source: New Scientist

"We can still act and it won’t be too late," says Obama

Former US President Barack Obama has written an op-ed piece in the Guardian giving his views on some of the greatest challenges facing the world – food and climate change – and what we can do about them. "We can still act and it won’t be too late," writes Obama.

Source: The Guardian

Juno mission: Jupiter’s magnetic field is even weirder than expected

It has long been known that Jupiter has the most intense magnetic field in the solar system, but the first round of results from NASA’s Juno mission has revealed that it is far stronger and more misshapen than scientists predicted.

Announcing the findings of the spacecraft’s first data-collection pass, which saw Juno fly within 2,600 miles (4,200km) of Jupiter on 27th August 2016, NASA mission scientists revealed that the planet far surpassed the expectations of models.

Measuring Jupiter’s magnetosphere using Juno’s magnetometer investigation (MAG) tool, they found that the planet’s magnetic field is even stronger than models predicted, at 7.766 Gaus: 10 times stronger than the strongest fields on Earth.

Furthermore, it is far more irregular in shape, prompting a re-think about how it could be generated.

“Juno is giving us a view of the magnetic field close to Jupiter that we’ve never had before,” said Jack Connerney, Juno deputy principal investigator and magnetic field investigation lead at NASA’s Goddard Space Flight Center in Greenbelt, Maryland.

“Already we see that the magnetic field looks lumpy: it is stronger in some places and weaker in others.

An enhanced colour view of Jupiter’s south pole. Image courtesy of NASA/JPL-Caltech/SwRI/MSSS/Gabriel Fiset. Featured image courtesy of NASA/SWRI/MSSS/Gerald Eichstädt/Seán Doran

At present, scientists cannot say for certain why or how Jupiter’s magnetic field is so peculiar, but they do already have a theory: that the field is not generated from the planet’s core, but in a layer closer to its surface.

“This uneven distribution suggests that the field might be generated by dynamo action closer to the surface, above the layer of metallic hydrogen,” said Connerney.

However, with many more flybys planned, the scientists will considerable opportunities to learn more about this phenomenon, and more accurately pinpoint the bizarre magnetic field’s cause.

“Every flyby we execute gets us closer to determining where and how Jupiter’s dynamo works,” added Connerney.

With each flyby, which occurs every 53 days, the scientists are treated to a 6MB haul of newly collected information, which takes around 1.5 days to transfer back to Earth.

“Every 53 days, we go screaming by Jupiter, get doused by a fire hose of Jovian science, and there is always something new,” said Scott Bolton, Juno principal investigator from the Southwest Research Institute in San Antonio.

A newly released image of Jupiter’s stormy south pole. Image courtesy of NASA/JPL-Caltech/SwRI/MSSS/Betsy Asher Hall/Gervasio Robles

An unexpected magnetic field was not the only surprise from the first data haul. The mission also provided a first-look at Jupiter’s poles, which are unexpectedly covered in swirling, densely clustered storms the size of Earth.

“We’re puzzled as to how they could be formed, how stable the configuration is, and why Jupiter’s north pole doesn’t look like the south pole,” said Bolton. “We’re questioning whether this is a dynamic system, and are we seeing just one stage, and over the next year, we’re going to watch it disappear, or is this a stable configuration and these storms are circulating around one another?”

Juno’s Microwave Radiometer (MWR) also threw up some surprises, with some of the planet’s belts appearing to penetrate down to its surface, while others seem to evolve into other structures. It’s a curious phenomenon, and one which the scientists hope to better explore on future flybys.

“On our next flyby on July 11, we will fly directly over one of the most iconic features in the entire solar system – one that every school kid knows – Jupiter’s Great Red Spot,” said Bolton.

“If anybody is going to get to the bottom of what is going on below those mammoth swirling crimson cloud tops, it’s Juno and her cloud-piercing science instruments.”