Stem cell therapy restores sight to blind mice

A transplantation treatment based on stem cells has moved closer to being tested in humans with severe vision problems, after successful trials in mice.

The method, which was shown to restore visual function in half of mice with end-stage retinal degeneration, involved transplanting retinal tissue derived from mouse induced pluripotent stem cells (iPSCs) into the host retina.

In order to create the transplant tissue, researchers first genetically reprogrammed skin cells taken from adult mice to an embryonic stem cell-like state before converting these iPSCs into retinal tissue. When transplanted into mice with end-stage retinal degeneration, the iPSC-derived retinal tissue developed to form photoreceptors that established direct contact with neighbouring cells in the retina.

The treatment, developed by senior study author Masayo Takahashi and first author Michiko Mandai of the RIKEN Center for Developmental Biology, was able to restore vision in roughly half of the mice with end-stage retinal degeneration. The research team are now testing the ability to replicate the results using human-derived iPSC retinal tissue.

“It is still a developing-stage therapy, and one cannot expect to restore practical vision at the moment,” Takahashi cautioned. “We will start from the stage of seeing a light or large figure, but hope to restore more substantial vision in the future.”

End-stage retinal degeneration is a leading cause of irreversible vision loss and blindness in older individuals. There is currently no cure and therapies are limited in their capability to stop the progression of vision loss.

The therapy strategy used by the RIKEN team is that of cell replacement, a method that, until now, suffered from uncertainty as to whether transplantation of stem cell tissues could actually restore visual function.

The key to success found by the researchers was the use of differentiated retinal tissues as opposed to retinal cells, which have previously been the focus of field use for most researchers. In almost all of the retinas that were transplanted, the researchers found at least some measure of response to light stimulation.

“The photoreceptors in the 3D structure can develop to form more mature, organized morphology, and therefore may respond better to light,” Takahashi explains. “From our data, the post-transplantation retina can respond to light already at one month in mice, but since the human retina takes a longer time to mature, it may take five to six months for the transplanted retina to start responding to light.”

Although simple light perception isn’t full restoration of sight, it is indicative of the possibilities of the treatment and shows that visual functions can be restored.

Takahashi’s acknowledgement of the increased complexity of human cells requires bearing in mind; it will not be a simple switchover from mice to human patients. However, if their new experiments into human-derived tissues prove successful, it may not be long before work can begin transferring this restorative success to clinical trials.

Scientists implant device to boost human memory

Scientists have enhanced human memory for the first time with a “memory prosthesis” brain implant. The team behind the device say it can boost performance on memory tests by up to 30%, and a similar approach may work for enhancing other brain skills, such as vision or movement.

Source: New Scientist

Astronomers discover Earth-sized world 11 light years away

A planet, Ross 128 b, has been discovered in orbit around a red dwarf star just 11 light years from the Sun. The planet is 35% more massive than Earth, and it likely exists at the edge of the small, relatively faint star's habitable zone even though it is 20 times closer to its star than the Earth is to the Sun.

Source: Ars Technica

An algorithm can see what you've learned before going to sleep

Researcher fed the brain activity from sleeping subjects to a machine learning algorithm, and it was able to determine what the subject had learned before falling asleep. In other words, an algorithm was able to effectively ‘read’ electrical activity from sleeping brains and determine what they were memorising as a result.

Source: Motherboard

Elon Musk unveils Tesla Truck and Tesla Roadster

Elon Musk has unveiled the long-anticipated 'Tesla Semi' – the company's first electric articulated lorry. The vehicle has a range of 500 miles on a single charge, and will go into production in 2019. Unexpectedly, Tesla also revealed a new Roadster, which will have a range of close to 1,000km (620 miles) on a single charge and will do 0-100mph in 4.2 seconds.

Source: BBC

Arrivo plans to build 200mph hyperloop-lite track

Arrivo, the company founded by former Hyperloop One engineer Brogan BamBrogan, has announced a partnership with Colorado’s Department of Transportation. Arrivo will now build a magnetised track to transport existing vehicles, cargo sleds and specially designed vehicles alongside preexisting freeways at 200mph in the city of Denver.

Source: The Verge

Boston Dynamics' Atlas robot can now do backflips

It's been a busy week for Boston Dynamics, first the company revealed it SpotMini robot dog was getting an upgrade, and now the company has shared a video of its Atlas humanoid robot leaping from platforms and doing a backflip. It seems like an obvious thing to say, but it's not easy to make a robot do a backflip, so how Boston Dynamics has managed it is anyone's guess.

Source: WIRED

The all new Factor Magazine is here – your guide to how today, tomorrow and beyond are being shaped

Guess who’s back, back again.

It’s been a few months, but Factor has returned with a bigger and better format, bringing the same future news and discussion, but on a platform that you can read on any device.

We’ve been working towards this for a long, long time: this is how we’ve always wanted the magazine to look, and we’re so happy to share this with you. It can be viewed on any web browser, on anything from a mobile to a monster PC, and if you’re on a desktop or laptop, click the button in the bottom right-hand corner for the ultimate shiny reading experience. A digital magazine has never looked this good. Probably.

Unfortunately that means no more iPad app, but as you can easily read the magazine from an iPad web browser, we hope you’ll agree that what we’ve gained is so much better than what’s been lost.

So anyway, here it is: the Winter 2017 issue of Factor, the first issue of the quarterly version of the magazine.

In case any of you are worrying about us publishing the magazine quarterly, trust us you don’t need to. We’ve produced the biggest issue of Factor ever, so packed with futuristic awesomeness, that we’ve had to divide it into three sections: Today, Tomorrow and Beyond.

Today deals with the futuristic present, as much of what we think of as ‘the future’ already exists today. We look at how humanoid robots are being employed as co-workers, hear from the legendary Richard Stallman about the vanishing state of privacy and discover how automation is already taking jobs. Plus, we take a light hearted look at the futuristic world of Mr Tesla, Elon Musk, and provide our festive present suggestions in a bumper futuristic gift guide.

Moving on to Tomorrow, and it’s all about the world of the next few decades, as technologies that are in development now reach fruition and seep into our everyday lives. We consider how flying cars are inching towards reality, with a look at both Lilium and the newly announced UberAir, and find out how driverless delivery may be the first true instance of the self-driving future.  Plus, we also look at the Christmas dinners of the future, because why the hell not.

Finally, in Beyond we look at the way-out future that many of us probably won’t live to see, but is supremely cool to think about. We ask leading futurists to predict what’s in store in the 22nd century – not the most positive of pictures, unfortunately – and consider what jobs will remain in a post-automation world. Plus, we look at the potential first homes of the human race beyond the solar system, and check out how asteroid mining is set to shape off-earth development.

Take a look, and if you like what you see and read, please share the magazine with your friends, or tell us what you think. This is a completely free magazine, with not an ad in sight, so it’s always good to know that it’s worth the effort.