Host of genetic research groups issue backing for inheritable human gene editing

A group of 11 organisations spanning five continents have issued a policy statement in support of current efforts to edit human germline genomes – that is, genes which passed down from parent to child.

The statement, published today in The American Journal of Human Genetics, said that the organisations support publicly funded in-vitro research into germline genome editing, which could eventually be used to eliminate devastating inherited diseases.

However, they stopped short of supporting research that would lead to a human pregnancy, arguing that at this stage it would be inappropriate to undertake.

“Our workgroup on genome editing included experts in several subfields of human genetics as well as from countries with varying health systems and research infrastructure,” said statement lead author Kelly E Ormond, professor of genetics at Stanford University.

“Given this diversity of perspective, we are encouraged by the agreement we were able to reach and hope it speaks to the soundness and wider acceptability of our recommendations.”

A depiction of the now widespread CRISPR-CAS9 gene editing complex, which enables DNA to be edited. Image courtesy of Image courtesy of Ian Slaymaker, Broad Institute

Germline genome editing has only been even hypothetically possible very recently, with the development of the CRISPR/Cas9 genome editing tool in 2013. Allowing precise customisation of genes, it creates whole new possibilities for genetic research, particularly in humans.

However, while scientists feel confident of the technological and scientific prospects, the technology raises significant ethical issues, particularly in germline genomes, where any changes could have an impact for generations.

As a result, the scientists argue that there needs to be strong public discussion about the ethical issues, as well as clear rationale, evidence and ethical justifications for any future research in the area.

“While germline genome editing could theoretically be used to prevent a child being born with a genetic disease, its potential use also raises a multitude of scientific, ethical, and policy questions,” said Derek T Scholes, ASHG director of science policy. “These questions cannot all be answered by scientists alone, but also need to be debated by society.”

“As basic science research into genome editing progresses in the coming years, we urge stakeholders to have these important ethical and social discussions in tandem,” added Ormond.

Conventional two-stranded DNA

As a result, it is likely that we will see far more public discussion before the first gene-edited babies come anywhere close to being conceived.

The statement was authored by the American Society of Human Genetics (ASHG), the Association of Genetic Nurses and Counsellors, the Canadian Association of Genetic Counsellors, the International Genetic Epidemiology Society, and the National Society of Genetic Counselors. It was also endorsed by the American Society for Reproductive Medicine, the Asia Pacific Society of Human Genetics, the British Society for Genetic Medicine, the Human Genetics Society of Australasia, the Professional Society of Genetic Counselors in Asia and the Southern African Society for Human Genetics.

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Skydio unveils its obstacle-dodging, thrill-seeking, AI-powered drone

An autonomous drone startup founded by former MIT researchers has today launched its R1, a fully autonomous flying camera that follows its subjects through dense and challenging environments.

In a promotional video, launched to introduce the autonomous camera, R1 can be seen following an athlete as she parkours her way through dense woodland.

The drone’s makers Skydio have explained that the camera combines artificial intelligence, computer vision, and advanced robotics and works by anticipating how people move, so R1 can make intelligent decisions about how to get the smoothest, most cinematic footage in real-time.

“The promise of the self-flying camera has captured people’s imaginations, but today’s drones still need to be flown manually for them to be useful,” said Adam Bry, CEO and co-founder of Skydio.

“We’ve spent the last four years solving the hard problems in robotics and AI necessary to make fully autonomous flight possible. We’re incredibly excited about the creative possibilities with R1, and we also believe that this technology will enable many of the most valuable drone applications for consumers and businesses over the coming years.”

Launching today is the Frontier Edition of R1, which is aimed at athletes, adventurers, and creators.

This version of R1 is powered by the Skydio Autonomy Engine, enabling it to see and understand the world around it so that it can fly safely at speeds of upto 25mph while avoiding obstacles.

The autonomous drone is fitted with 13 cameras, which gives it the ability to map and understand the world in real-time, allowing it to be fully autonomous and independently capture footage that in Skydio’s words “once required a Hollywood film crew” and will “enable a new type of visual storytelling”.

The R1 “Frontier Edition” is available for order now on Skydio’s website for $2,499.