Nanoengineers send antibiotic-delivering micromotors into the body to treat cancer-causing infection

Nanoengineers have demonstrated for the first time how “micromotors” that measure half the width of a human hair can be used to transport antibiotics through the body.

Nanoengineers at the University of California San Diego tested the micromotors in mice with Helicobacter pylori infections, which can also be found in about two-thirds of the world’s population and while many people will never notice any signs of its presence it can cause peptic ulcers and stomach cancer.

The mice received the micromotors – packed with a clinical dose of the antibiotic clarithromycin – orally once a day for five consecutive days.

Afterwards, nanoengineers evaluated the bacterial count in each mouse stomach and found that treatment with the micromotors was slightly more effective than when the same dose of antibiotic was given in combination with proton pump inhibitors, which also suppress gastric acid production.

Micromotors administered to the mice swam rapidly throughout the stomach while neutralising gastric acid, which can be destructive to orally administered drugs such as antibiotics and protein-based pharmaceuticals.

Because gastric acid is so destructive to traditional antibiotics drugs used to treat bacterial infections, ulcers and other diseases in the stomach are normally taken with additional substances, called proton pump inhibitors.

But when taken over longer periods or in high doses, proton pump inhibitors can cause adverse side effects including headaches, diarrhea and fatigue. In more serious cases, they can cause anxiety or depression.

The micromotors, however, have a built-in mechanism that neutralises gastric acid and effectively deliver their drug payloads in the stomach without requiring the use of proton pump inhibitors.

“It’s a one-step treatment with these micromotors, combining acid neutralisation with therapeutic action,” said Berta Esteban-Fernández de Ávila, a postdoctoral scholar in Wang’s research group at UC San Diego and a co-first author of the paper.

The nanoengineers say that while the present results are promising, this work is still at an early stage.

To test their work, the team is planning future studies to into the therapeutic performance of the micromotors in animals and humans, and will compare it with other standard therapies used to combat stomach diseases.

UC San Diego nanoengineers also plan to test different drug combinations with the micromotors to treat multiple diseases in the stomach or in different sections of the gastrointestinal tract.

Overall, the researchers say that this work opens the door to the use of synthetic motors as active delivery platforms in the treatment of diseases.

Image and video courtesy of the Laboratory for Nanobioelectronics at UC San Diego.

Scientists implant device to boost human memory

Scientists have enhanced human memory for the first time with a “memory prosthesis” brain implant. The team behind the device say it can boost performance on memory tests by up to 30%, and a similar approach may work for enhancing other brain skills, such as vision or movement.

Source: New Scientist

Astronomers discover Earth-sized world 11 light years away

A planet, Ross 128 b, has been discovered in orbit around a red dwarf star just 11 light years from the Sun. The planet is 35% more massive than Earth, and it likely exists at the edge of the small, relatively faint star's habitable zone even though it is 20 times closer to its star than the Earth is to the Sun.

Source: Ars Technica

An algorithm can see what you've learned before going to sleep

Researcher fed the brain activity from sleeping subjects to a machine learning algorithm, and it was able to determine what the subject had learned before falling asleep. In other words, an algorithm was able to effectively ‘read’ electrical activity from sleeping brains and determine what they were memorising as a result.

Source: Motherboard

Elon Musk unveils Tesla Truck and Tesla Roadster

Elon Musk has unveiled the long-anticipated 'Tesla Semi' – the company's first electric articulated lorry. The vehicle has a range of 500 miles on a single charge, and will go into production in 2019. Unexpectedly, Tesla also revealed a new Roadster, which will have a range of close to 1,000km (620 miles) on a single charge and will do 0-100mph in 4.2 seconds.

Source: BBC

Arrivo plans to build 200mph hyperloop-lite track

Arrivo, the company founded by former Hyperloop One engineer Brogan BamBrogan, has announced a partnership with Colorado’s Department of Transportation. Arrivo will now build a magnetised track to transport existing vehicles, cargo sleds and specially designed vehicles alongside preexisting freeways at 200mph in the city of Denver.

Source: The Verge

Boston Dynamics' Atlas robot can now do backflips

It's been a busy week for Boston Dynamics, first the company revealed it SpotMini robot dog was getting an upgrade, and now the company has shared a video of its Atlas humanoid robot leaping from platforms and doing a backflip. It seems like an obvious thing to say, but it's not easy to make a robot do a backflip, so how Boston Dynamics has managed it is anyone's guess.

Source: WIRED

The all new Factor Magazine is here – your guide to how today, tomorrow and beyond are being shaped

Guess who’s back, back again.

It’s been a few months, but Factor has returned with a bigger and better format, bringing the same future news and discussion, but on a platform that you can read on any device.

We’ve been working towards this for a long, long time: this is how we’ve always wanted the magazine to look, and we’re so happy to share this with you. It can be viewed on any web browser, on anything from a mobile to a monster PC, and if you’re on a desktop or laptop, click the button in the bottom right-hand corner for the ultimate shiny reading experience. A digital magazine has never looked this good. Probably.

Unfortunately that means no more iPad app, but as you can easily read the magazine from an iPad web browser, we hope you’ll agree that what we’ve gained is so much better than what’s been lost.

So anyway, here it is: the Winter 2017 issue of Factor, the first issue of the quarterly version of the magazine.

In case any of you are worrying about us publishing the magazine quarterly, trust us you don’t need to. We’ve produced the biggest issue of Factor ever, so packed with futuristic awesomeness, that we’ve had to divide it into three sections: Today, Tomorrow and Beyond.

Today deals with the futuristic present, as much of what we think of as ‘the future’ already exists today. We look at how humanoid robots are being employed as co-workers, hear from the legendary Richard Stallman about the vanishing state of privacy and discover how automation is already taking jobs. Plus, we take a light hearted look at the futuristic world of Mr Tesla, Elon Musk, and provide our festive present suggestions in a bumper futuristic gift guide.

Moving on to Tomorrow, and it’s all about the world of the next few decades, as technologies that are in development now reach fruition and seep into our everyday lives. We consider how flying cars are inching towards reality, with a look at both Lilium and the newly announced UberAir, and find out how driverless delivery may be the first true instance of the self-driving future.  Plus, we also look at the Christmas dinners of the future, because why the hell not.

Finally, in Beyond we look at the way-out future that many of us probably won’t live to see, but is supremely cool to think about. We ask leading futurists to predict what’s in store in the 22nd century – not the most positive of pictures, unfortunately – and consider what jobs will remain in a post-automation world. Plus, we look at the potential first homes of the human race beyond the solar system, and check out how asteroid mining is set to shape off-earth development.

Take a look, and if you like what you see and read, please share the magazine with your friends, or tell us what you think. This is a completely free magazine, with not an ad in sight, so it’s always good to know that it’s worth the effort.