Scientists develop lab-grown bone using tech originally used to detect gravitational waves

Scientists have described how technology originally developed to detect gravitational waves can be used to generate lab-grown bone.

Universities of Glasgow, Strathclyde, the West of Scotland and Galway scientists have developed the technique known as nanokicking, which allows scientists to grow three-dimensional samples of mineralised bone in the laboratory for the first time.

The technique could eventually be used to repair or replace damaged sections of bone in humans.

“This is an exciting step forward for nanokicking, and it takes us one step further towards making the technique available for use in medical therapies,” said Matthew Dalby, professor of cell engineering at the University of Glasgow.

“Now that we have advanced the process to the point where it’s readily reproducible and affordable, we will begin our first human trials around three years from now in the NHS along with the Scottish National Blood Transfusion Service and reconstructive and orthopaedic surgeons in Glasgow.”

Although bone is the second most grafted tissue after blood and is used in reconstructive, orthopaedic and cosmetic surgeries, currently surgeons can only harvest limited amounts of living bone from the patient for use in a graft, and bone from other donors is likely to be rejected by the body.

Instead, at the minute, surgeons have to rely on inferior donor sources that contain no cells capable of regenerating bone, which limits the size of repairs they can affect.

“For many people who have lost legs in landmine accidents, the difference between being confined to a wheelchair and being able to use a prosthesis could be only a few centimetres of bone,” said professor of bioengineering at the University of Glasgow Manuel Salmeron-Sanchez.

However, the process of nanokicking subjects cells to ultra-precise, nanoscale vibrations while they are suspended inside collagen gels.

The cells in the gels are the turned into a ‘bone putty’ that has the potential to be used to heal bone fractures and fill bone where there is a gap.

Using patients’ own mesenchymal cells, which are naturally produced by the human body in bone marrow, surgeons will be able to prevent the problem of rejection, and can bridge larger gaps in bone.

Before beginning human trials, the nanokicking technique developed by the researchers is currently being further tested in a network of laboratories across the UK.

“We have already proven the effectiveness of our scaffolds in veterinary medicine, by helping to grow new bone to save the leg of a dog who would otherwise have had to have it amputated,” said Dalby.

“Combining bone putty and mechanically strong scaffolds will allow us to address large bone deficits in humans in the future.”

The scientists work has been funded by Sir Bobby Charlton’s landmine charity Find a Better Way, which help individuals and communities heal from the devastating impact of landmines and other explosive remnants of war, and is published in Nature Biomedical Engineering.

Google’s Alphabet is Developing the Neighbourhood of the Future in Toronto

Alphabet, the parent company of Google, has announced that Sidewalk Labs, its urban innovation unit, will design a high-tech neighbourhood on Toronto’s waterfront. The neighbourhood, called Quayside, will prioritise, “environmental sustainability, affordability, mobility and economic opportunity”.

The initial phase for the development, part of the broader Sidewalk Toronto project, has received a $50m commitment from Sidewalk, but is predicted to cost at least a billion dollars by the time it’s fully completion.

As part of the broader project, Quayside seems to be the first attempt at creating what Sidewalk refers to as a “new kind of mixed-use, complete community”, an attempt the company presumably hopes to eventually expand across the waterfront and ultimately into other cities.

“This will not be a place where we deploy technology for its own sake, but rather one where we use emerging digital tools and the latest in urban design to solve big urban challenges in ways that we hope will inspire cities around the world,” Sidewalk Labs CEO Dan Doctoroff said on Tuesday.

Early concept images for the neighbourhood include self-driving cars and other infrastructure technologies. Images courtesy of Sidewalk Toronto

Located in the primarily publicly-owned 800-acre area called Port Lands, Quayside looks to be the test bed for potential future community design. With the planning process for the development starting with a community town hall on the 1st of November, we are still some ways off from knowing just what the neighbourhood will look like, but early illustrations include bikeshares, apartment housing, bus lines and parks.

More importantly, however, is Doctoroff’s previous discussions of what he believes future city design will look like. Technology focused, there’s been mention of sensors that track energy usage, machine learning and using high-speed internet to improve urban environments.

Specifically, at a summit hosted by The Information last year, he mentioned “thinking about [a city] from the internet up”. As would be expected from a company under the same parent as Google, Sidewalk seems to be concentrated on development that prioritises innovation and building communities with an eye to how technology can help found neighbourhoods.

“I like to describe it that we’re in the very early stages of what I call the fourth revolution of urban technology,” Doctoroff previously told Business Insider.

“The first three were the steam engine, which brought through trains and factories that industrialized cities. The second was the electric grid, which made cities 24 hours, made them more vertical, made them easier to get around in with subways and streetcars.

“The third was the automobile, which forced us to really re-think the use of public space in order to protect people from the danger of the automobile. We’re now in the fourth one. We’ve had an urban technology revolution … We’re seeing a real change in the physical nature of our cities.”

DJI’s First Drone Arena in Tokyo to Open This Saturday

Consumer drone giant DJI will open its first Japanese drone arena in the city of Tokyo this Saturday, providing a space for both hardened professionals and curious newcomers to hone their flying skills.

The arena, which covers an area of 535 square metres, will not only include a large flying area complete with obstacles, but also offer a store where visitors can purchase the latest DJI drones and a technical support area where drone owners can get help with quadcopter issues.

The hope is that the arena will allow those who are curious about the technology but currently lack the space to try it out to get involved.

“As interest around our aerial technology continues to grow, the DJI Arena concept is a new way for us to engage not just hobbyists but also those considering this technology for their work or just for the thrill of flying,” said Moon Tae-Hyun, DJI’s director of brand management and operations.

“Having the opportunity to get behind the remote controller and trying out the technology first hand can enrich the customer experience. When people understand how it works or how easy it is to fly, they will discover what this technology can do for them and see a whole new world of possibilities.”

Images courtesy of DJI

In addition to its general sessions, which will allow members of the public to drop by and try their hand at flying drones, the arena will also offer private hire, including corporate events. For some companies, then, drone flying could become the new golf.

There will also be regular events, allowing pros to compete against one another, and drone training, in the form of DJI’s New Pilot Experience Program, for newcomers.

The arena has been launched in partnership with Japan Circuit, a developer of connected technologies, including drones.

“We are extremely excited to partner with DJI to launch the first DJI Arena in Japan,” said Tetsuhiro Sakai, CEO of Japan Circuit.

“Whether you are a skilled drone pilot or someone looking for their first drone, we welcome everyone to come and learn, experience it for themselves, and have fun. The new DJI Arena will not only serve as a gathering place for drone enthusiasts but also help us reach new customers and anyone interested in learning about this incredible technology.”

The arena is the second of its kind to be launched by DJI, with the first located in Yongin, South Korea, and detailed in the video above. .

Having opened in 2016, the area has attracted visitors from around the world, demonstrating serious demand for this type of entertainment space.

If the Tokyo launch goes well, it’s likely DJI will look at rolling out its arena concept to other cities, perhaps even bringing the model to the US and Europe.

For now, however, those who are interested can book time at the Tokyo arena here.