Scientists, software developers and artists have begun using VR to visualise genes and predict disease

A group of scientists, software developers and artists have taken to using virtual reality (VR) technology to visualise complex interactions between genes and their regulatory elements.

The team, which comprises of members from Oxford University, Universita’ di Napoli and Goldsmiths, University of London, have been using VR to visualise simulations of a composite of data from genome sequencing, data on the interactions of DNA and microscopy data.

When all this data is combined the team are provided with an interactive, 3D image that shows where different regions of the genome sit relative to others, and how they interact with each other.

“Being able to visualise such data is important because the human brain is very good at pattern recognition – we tend to think visually,” said Stephen Taylor, head of the Computational Biology Research Group at Oxford’s MRC Weatherall Institute of Molecular Medicine (WIMM).

“It began at a conference back in 2014 when we saw a demonstration by researchers from Goldsmiths who had used software called CSynth to model proteins in three dimensions. We began working with them, feeding in seemingly incomprehensible information derived from our studies of the human alpha globin gene cluster and we were amazed that what we saw on the screen was an instantly recognisable model.”

The team believe that being able to visualise the interactions between genes and their regulatory elements will allow them to understand the basis of human genetic diseases, and are currently applying their techniques to study genetic diseases such as diabetes, cancer and multiple sclerosis.

“Our ultimate aim in this area is to correct the faulty gene or its regulatory elements and be able to re-introduce the corrected cells into a patient’s bone marrow: to perfect this we have to fully understand how genes and their regulatory elements interact with one another” said Professor Doug Higgs, a principal researcher at the WIMM.

“Having virtual reality tools like this will enable researchers to efficiently combine their data to gain a much broader understanding of how the organisation of the genome affects gene expression, and how mutations and variants affect such interactions.”

There are around 37 trillion cells in the average adult human body, and each cell contains two meters of DNA tightly packed into its nucleus.

While the technology to sequence genomes is well established, it has been shown that the manner in which DNA is folded within each cell affects how genes are expressed.

“There are more than three billion base pairs in the human genome, and a change in just one of these can cause a problem. As a model we’ve been looking at the human alpha globin gene cluster to understand how variants in genes and their regulatory elements may cause human genetic disease,” said Prof Jim Hughes, associate professor of Genome Biology at Oxford University.

Researchers believe modified CRISPR could be used without editing DNA

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Source: Gizmodo

Nissan to trial robo-taxis in Japan next year

The carmaker Nissan is is partnering with Japanese software company DeNA to test self-driving taxis on Japanese roads from March next year. The free trials will be held over a two-week period in March in Yokohama, and Nissan believes the service could be officially launched in Japan in the early 2020s.

Source: BBC

Apparently, gaming can save your brain

Research participants who played 3D platforming games like the iconic Super Mario 64 had more gray matter in their hippocampus after playing, That part of the brain transforms short-term memories into long-term ones and maintains the spatial memory that helps us navigate the world around us.

Source: Inverse

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Source: BBC

Steam stops accepting Bitcoin

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Source: Ars Technica

The maker of Budweiser beer reserves 40 Tesla electric trucks

Budweiser beer maker Anheuser-Busch has reserved 40 Tesla all-electric Semi trucks as it seeks to reduce fuel costs and vehicle emissions. The reservation is one of the largest publicly announced orders Tesla has received, while production of the trucks is scheduled to begin by 2019.

Source: Reuters

The UK government is launching a fintech competition to help renters get on the property ladder

The UK government is offering £2 million to fintech developers who come up with a tool that lets renters record and share their payment data.

The Rent Recognition Challenge, which was first announced as part of the chancellors’ autumn budget, will task developers with finding a way to record payment data from Britain’s 11 million renters in a bid to improve their credit scores and ultimately help them to get a mortgage.

“Most lenders and Credit Reference Agencies are unable to take rental data into account, because they don’t have access to it.

“The Rent Recognition Challenge will challenge firms to develop an innovative solution to this problem and help to restore the dream of home ownership for a new generation,” said the economic secretary to HM Treasury, Stephen Barclay.

Economic secretary to HM Treasury, Stephen Barclay. Image courtesy of Chris McAndrew

The competition will provide an initial round of grant funding to six promising proposals to help turn their ideas into workable products.

A panel of leading figures from the Fintech sector will then whittle the six down to just a handful of teams who will receive further funding and support to bring their ideas to market.

“People’s monthly rent is often their biggest expense, so it makes sense for it to be recognised when applying for a mortgage. Without a good credit score, getting a mortgage can be a real struggle.”

Image courtesy of Jeff Djevdet

The government’s attempt to help more people out of private renting arrangements and into home ownership comes after Scottish Widows published a report that warned tomorrow’s pensioners will have to find huge amounts of money to pay ever-escalating rents to private landlords.

Scottish Widows projected one in eight retirees will be renting by 2032, which works out to three times the number renting today. It also said there is a £43bn gap between the income and savings people have now and what the rent bill will be in retirement.

Speaking to the Guardian, Dan Wilson Craw of campaign group Generation Rent said: “The common perception is that retirees either own their home outright or have a council tenancy, so the government will be in for a nasty shock as more of us retire and continue to rent from a private landlord.

“Many renters relying on pensions will qualify for housing benefit which will put greater strain on the public finances.”

The Rent Recognition Challenge will open to applications early in the New Year, and development will conclude in October 2018.